Cobalt‐Catalyzed Reductive Cross‐Coupling Between Benzyl Chlorides and Aryl Halides | Zendy

Pal Suman | Zendy; Chowdhury Sushobhan | Zendy; Rozwadowski Elodie | Zendy; Auffrant Audrey | Zendy; Gosmini Corinne | Zendy

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Cobalt‐Catalyzed Reductive Cross‐Coupling Between Benzyl Chlorides and Aryl Halides

Author(s) -

Pal Suman,

Chowdhury Sushobhan,

Rozwadowski Elodie,

Auffrant Audrey,

Gosmini Corinne

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201600378

Subject(s) - chemistry , aryl , halide , cobalt , catalysis , pyridine , reductive elimination , coupling reaction , ligand (biochemistry) , combinatorial chemistry , medicinal chemistry , organic chemistry , alkyl , biochemistry , receptor

A new protocol for the direct reductive cobalt‐catalyzed arylation of benzyl chlorides has been developed in order to form functionalized diarylmethanes. A variety of reactive groups either on the aryl or the benzyl halide was employed. This represents the first cobalt‐catalyzed reductive cross‐coupling which does not require any ligand and pyridine. A reaction pathway is proposed involving a radical benzyl species.

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