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Cobalt‐Catalyzed Reductive Cross‐Coupling Between Benzyl Chlorides and Aryl Halides
Author(s) -
Pal Suman,
Chowdhury Sushobhan,
Rozwadowski Elodie,
Auffrant Audrey,
Gosmini Corinne
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600378
Subject(s) - chemistry , aryl , cobalt , halide , catalysis , pyridine , reductive elimination , coupling reaction , ligand (biochemistry) , combinatorial chemistry , medicinal chemistry , organic chemistry , alkyl , biochemistry , receptor
A new protocol for the direct reductive cobalt‐catalyzed arylation of benzyl chlorides has been developed in order to form functionalized diarylmethanes. A variety of reactive groups either on the aryl or the benzyl halide was employed. This represents the first cobalt‐catalyzed reductive cross‐coupling which does not require any ligand and pyridine. A reaction pathway is proposed involving a radical benzyl species.