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Mild and Direct Multiple Deuterium‐Labeling of Saturated Fatty Acids
Author(s) -
Yamada Tsuyoshi,
Park Kwihwan,
Yasukawa Naoki,
Morita Kosuke,
Monguchi Yasunari,
Sawama Yoshinari,
Sajiki Hironao
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600363
Subject(s) - chemistry , deuterium , isopropyl , isopropyl alcohol , solvent , hydrogen , fatty alcohol , alcohol , catalysis , organic chemistry , medicinal chemistry , quantum mechanics , physics
We have established a mild and direct platinum on carbon (Pt/C)‐catalyzed multi‐deuterium labeling of various saturated fatty acids including bioactive compounds with high deuterium efficiencies in a mixed solvent of isopropyl alcohol and deuterium oxide ( i‐ PrOH)/D 2 O under neutral conditions at 120 °C without the external addition of deuterium or hydrogen gas.