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An Environmentally Sustainable Mechanochemical Route to Hydroxamic Acid Derivatives
Author(s) -
Mocci Rita,
Luca Lidia De,
Delogu Francesco,
Porcheddu Andrea
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600350
Subject(s) - chemistry , mechanochemistry , ball mill , hydroxamic acid , carboxylic acid , organic chemistry , environmentally friendly , combinatorial chemistry , molecule , chemical engineering , ecology , biology , engineering
An operationally simple, and cost efficient conversion of carboxylic acids into hydroxamic acid derivatives via a high‐energy mechanochemical activation is presented. This ball milling methodology was applied to a wide variety of carboxylic acids dramatically improving purification issues associated with this class of molecules, which still remain one of the main bottlenecks of classical methodologies.