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The Reactivity of Difluorocarbene with Hydroxylamines: Synthesis of Carbamoyl Fluorides
Author(s) -
Baars Hannah,
Engel Julien,
Mertens Lucas,
Meister Daniela,
Bolm Carsten
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600308
Subject(s) - difluorocarbene , carbene , chemistry , reactivity (psychology) , phosphonate , organic chemistry , medicinal chemistry , catalysis , medicine , alternative medicine , pathology
Carbamoyl fluorides are formed in reactions of hydroxylamines with difluorocarbene generated from sodium bromodifluoroacetate as readily available and non‐toxic carbene precursor. The process shows a high functional group tolerance, and the reaction path has been rationalized by computational calculations.