Reagent/Substituent Switching Approach for the Synthesis of Substituted 1,3,4‐Oxadiazole/1,3,4‐Oxadiazoline and 1,2,4‐Triazole Derivatives from N‐Substituted Hydrazides | Zendy

Kotipalli Trimurtulu | Zendy; Kavala Veerababurao | Zendy; Konala Ashok | Zendy; Janreddy Donala | Zendy; Kuo ChuWei | Zendy; Yao ChingFa | Zendy

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Reagent/Substituent Switching Approach for the Synthesis of Substituted 1,3,4‐Oxadiazole/1,3,4‐Oxadiazoline and 1,2,4‐Triazole Derivatives from N‐Substituted Hydrazides

Author(s) -

Kotipalli Trimurtulu,

Kavala Veerababurao,

Konala Ashok,

Janreddy Donala,

Kuo ChuWei,

Yao ChingFa

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201600274

Subject(s) - oxadiazole , chemistry , substituent , reagent , triazole , pyridine , combinatorial chemistry , triflic acid , organic chemistry , medicinal chemistry , catalysis

A metal‐free method for the synthesis of substituted 1,3,4‐oxadiazole/1,3,4‐oxadiazoline and 1,2,4‐triazole derivatives from a common starting material via reagent/substituent switching is reported. In the presence of 2‐fluoropyridine/triflic anhydride, 1,3,4‐oxadiazole derivatives were exclusively formed from N′‐tert ‐butylhydrazides and 1,3,4‐oxadiazoline derivatives were produced from N ‐phenylhydrazides. On the other hand, when using pyridine/triflic anhydride, salts of 1,2,4‐triazoles were the sole products.

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