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Copper‐Catalyzed Addition of Alkylboranes to Iminoacetates: Access to α‐Alkyl Branched α‐Amino Acids
Author(s) -
Xiao Xinsheng,
Zhang Wei,
Lu Xiaoxia,
Deng Yuanfu,
Jiang Huangfeng,
Zeng Wei
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600248
Subject(s) - chemistry , alkyl , reagent , copper , catalysis , transformation (genetics) , organic chemistry , amino acid , combinatorial chemistry , biochemistry , gene
A copper(I)‐catalyzed addition of alkylborane reagents to α‐iminoacetates has been developed to assemble both acyclic and cyclic α‐branched α‐amino carboxylic acid derivatives in good yields. A wide variety of unactivated alkenes are well tolerated in this transformation.