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Disulfides as Sulfonylating Precursors for the Synthesis of Sulfone‐Containing Oxindoles
Author(s) -
Zhang MingZhong,
Ji PengYi,
Liu YuFeng,
Xu JingWen,
Guo CanCheng
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600200
Subject(s) - sulfone , chemistry , potassium persulfate , persulfate , aqueous solution , organic chemistry , combinatorial chemistry , catalysis , monomer , polymer
The first facile one‐pot synthesis of sulfone‐containing oxindoles with easily accessible disulfides as the sulfonylating precursors is described. This reaction occurs smoothly under transition metal‐free conditions and shows excellent functional group tolerance, allowing the facile and efficient green synthesis of various sulfone‐containing oxindoles in aqueous solution. Preliminary mechanistic studies reveal that both water (H 2 O) and potassium persulfate (K 2 S 2 O 8 ) can be the oxygen source of the sulfone groups in the products.