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One‐Pot Synthesis of 4‐Heteroaryl‐Substituted Pyrazoles: A Gold‐Catalyzed Oxidation/1,2‐Heteroaryl Migration Cascade Constitutes the Key Step
Author(s) -
Yao Xinbo,
Wang Tao,
Zhang Xi,
Wang Ping,
Zhang Bing,
Wei Junfa,
Zhang Zunting
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600168
Subject(s) - chemistry , combinatorial chemistry , pyrazole , one pot synthesis , substrate (aquarium) , cascade , catalysis , cascade reaction , two step , one step , organic chemistry , stereochemistry , oceanography , chromatography , geology , art , visual arts
An efficient gold‐catalyzed oxidation/1,2‐ heteroaryl migration cascade leading to 2‐heteroaryl‐substituted 1,3‐diketones and its further application in the one‐pot synthesis of 4‐heteroaryl‐substituted pyrazoles and the preparation of 4‐heteroaryl‐substituted isoxazoles are reported. A wide variety of 4‐heteroaryl‐substituted pyrazoles were obtained, indicating the broad substrate scope and functional group tolerance of this method.