One‐Pot Synthesis of 4‐Heteroaryl‐Substituted Pyrazoles: A Gold‐Catalyzed Oxidation/1,2‐Heteroaryl Migration Cascade Constitutes the Key Step | Zendy

Yao Xinbo | Zendy; Wang Tao | Zendy; Zhang Xi | Zendy; Wang Ping | Zendy; Zhang Bing | Zendy; Wei Junfa | Zendy; Zhang Zunting | Zendy

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One‐Pot Synthesis of 4‐Heteroaryl‐Substituted Pyrazoles: A Gold‐Catalyzed Oxidation/1,2‐Heteroaryl Migration Cascade Constitutes the Key Step

Author(s) -

Yao Xinbo,

Wang Tao,

Zhang Xi,

Wang Ping,

Zhang Bing,

Wei Junfa,

Zhang Zunting

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201600168

Subject(s) - chemistry , combinatorial chemistry , pyrazole , one pot synthesis , substrate (aquarium) , cascade , catalysis , cascade reaction , two step , one step , organic chemistry , stereochemistry , oceanography , chromatography , geology , art , visual arts

An efficient gold‐catalyzed oxidation/1,2‐ heteroaryl migration cascade leading to 2‐heteroaryl‐substituted 1,3‐diketones and its further application in the one‐pot synthesis of 4‐heteroaryl‐substituted pyrazoles and the preparation of 4‐heteroaryl‐substituted isoxazoles are reported. A wide variety of 4‐heteroaryl‐substituted pyrazoles were obtained, indicating the broad substrate scope and functional group tolerance of this method.

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