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Manganese‐Catalyzed ortho ‐C−H Alkenylation of Aromatic N−H Imidates with Alkynes: Versatile Access to Mono ‐Alkenylated Aromatic Nitriles
Author(s) -
Yang Xiaoxu,
Jin Xiqing,
Wang Congyang
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600128
Subject(s) - chemistry , manganese , catalysis , selectivity , stereoselectivity , aromaticity , medicinal chemistry , combinatorial chemistry , organic chemistry , molecule
So far, the direct C−H alkenylation of aromatic nitriles with alkynes has not been achieved. Herein, we discribe the first manganese‐catalyzed C−H alkenylation of aromatic N−H imidates to access mono ‐alkenylated aromatic nitriles. The reaction is accelerated by the presence of a catalytic amount of sodium pivalate. This protocol is also highlighted by the simple catalytic system, good compatibility of functional groups, and excellent mono‐/dialkenylation selectivity as well as E / Z stereoselectivity.