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Cover Picture: Synthesis of Substituted Quinolizidines via a Gold‐Catalyzed Double Cyclization Cascade (Adv. Synth. Catal. 3/2016)
Author(s) -
aka Shiori,
Sugimoto Kenji,
Ueda Hirofumi,
Tokuyama Hidetoshi
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600054
Subject(s) - quinolizidine , chemistry , cascade , catalysis , combinatorial chemistry , stereochemistry , cascade reaction , organic chemistry , alkaloid , chromatography
The cover picture , provided by Hidetoshi Tokuyama and co‐workers, illustrates the synthesis of substituted quinolizidines via the gold‐catalyzed double cyclization cascade. The gold catalyst is efficient for the syntheses of multi‐substituted quinolizidine derivatives via the double cyclization of acyclic substrates. The advantage of this reaction is the modular synthesis of acyclic substrates by switching three segments. The gold‐catalyzed cascade reaction enables the preparation of various quinolizidine derivatives efficiently. Details can be found in the Communication on pages 380–385 (S. Nonaka, K. Sugimoto, H. Ueda, H. Tokuyama, Adv. Synth. Catal. 2016 , 358 , 380–385; DOI: 10.1002/adsc.201500907 ).