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Cover Picture: Synthesis of 3,3‐Disubstituted Oxindoles Containing a 3‐(4‐Aminobut‐2‐ynyl) Unit via Domino Heck–Sonogashira Reaction in Water (Adv. Synth. Catal. 3/2016)
Author(s) -
Wang DongChao,
Wang HaiXia,
Hao ErJun,
Jiang XiaoHan,
Xie MingSheng,
Qu GuiRong,
Guo HaiMing
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600052
Subject(s) - sonogashira coupling , chemistry , domino , oxindole , heck reaction , palladium , quaternary carbon , stereochemistry , combinatorial chemistry , medicinal chemistry , catalysis , organic chemistry , enantioselective synthesis
The cover picture , provided by Hai‐Ming Guo, Gui‐Rong Qu and co‐workers, illustrates a palladium‐catalyzed domino HeckSonogashira process in water. Using this strategy, a series of 3‐(4‐aminobut‐2ynyl)oxindole derivatives with an all‐carbon quaternary center at the 3‐position was easily synthesized. The reactions provided products in excellent yields with a broad substrate tolerance. The target product was readily converted into a pharmaceutically active molecule, which is used as a 5‐HT 7 receptor antagonist. Details can be found in the Update on pages 494–499 (D.‐C. Wang, H.‐X. Wang, E.‐J. Hao, X.‐H. Jiang, M.‐S. Xie, G.‐R. Qu, H.‐M. Guo, Adv. Synth. Catal. 2016 , 358 , 494–499; DOI: 10.1002/adsc.201500887 ).