Cover Picture: Synthesis of 3,3‐Disubstituted Oxindoles Containing a 3‐(4‐Aminobut‐2‐ynyl) Unit  via  Domino Heck–Sonogashira Reaction in Water (Adv. Synth. Catal. 3/2016) | Zendy

Wang DongChao | Zendy; Wang HaiXia | Zendy; Hao ErJun | Zendy; Jiang XiaoHan | Zendy; Xie MingSheng | Zendy; Qu GuiRong | Zendy; Guo HaiMing | Zendy

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Cover Picture: Synthesis of 3,3‐Disubstituted Oxindoles Containing a 3‐(4‐Aminobut‐2‐ynyl) Unit via Domino Heck–Sonogashira Reaction in Water (Adv. Synth. Catal. 3/2016)

Author(s) -

Wang DongChao,

Wang HaiXia,

Hao ErJun,

Jiang XiaoHan,

Xie MingSheng,

Qu GuiRong,

Guo HaiMing

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201600052

Subject(s) - sonogashira coupling , chemistry , domino , oxindole , heck reaction , palladium , quaternary carbon , stereochemistry , combinatorial chemistry , medicinal chemistry , catalysis , organic chemistry , enantioselective synthesis

The cover picture , provided by Hai‐Ming Guo, Gui‐Rong Qu and co‐workers, illustrates a palladium‐catalyzed domino HeckSonogashira process in water. Using this strategy, a series of 3‐(4‐aminobut‐2ynyl)oxindole derivatives with an all‐carbon quaternary center at the 3‐position was easily synthesized. The reactions provided products in excellent yields with a broad substrate tolerance. The target product was readily converted into a pharmaceutically active molecule, which is used as a 5‐HT 7 receptor antagonist. Details can be found in the Update on pages 494–499 (D.‐C. Wang, H.‐X. Wang, E.‐J. Hao, X.‐H. Jiang, M.‐S. Xie, G.‐R. Qu, H.‐M. Guo, Adv. Synth. Catal. 2016 , 358 , 494–499; DOI: 10.1002/adsc.201500887 ).

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