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Zinc Iodide‐Mediated Direct Synthesis of 2,3‐Dihydroisoxazoles from Alkynes and Nitrones
Author(s) -
Xiao ZuFeng,
Ding TingHui,
Mao ShengWei,
Ning XiaoShan,
Kang YanBiao
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600044
Subject(s) - chemistry , cycloaddition , zinc , formal synthesis , nitrone , iodide , combinatorial chemistry , organic chemistry , catalysis
A zinc diiodide (ZnI 2 )‐mediated direct synthesis of 2,3‐dihydroisoxazoles via a [3+2] cycloaddition reaction of the nitrones and non‐electron‐deficient terminal alkynes has been developed. This method was applied in the formal synthesis of HPA‐12 and aminoglucose.