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Gold‐Catalyzed Cycloisomerizations of 1, n ‐Diyne Carbonates and Esters
Author(s) -
Day David Philip,
Chan Philip Wai Hong
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201600005
Subject(s) - chemistry , propargyl , catalysis , combinatorial chemistry , homogeneous , homogeneous catalysis , reactivity (psychology) , cycloisomerization , substrate (aquarium) , organic molecules , organic chemistry , molecule , nanotechnology , medicine , physics , alternative medicine , oceanography , materials science , pathology , thermodynamics , geology
Driven by the ever‐growing need for efficient methods to prepare synthetically valuable complex molecules, homogeneous gold catalysis has emerged as an invaluable addition in the organic chemist's toolbox to achieve such goals. Within this field of catalysis, this review focuses on the contributions made toward the construction of core structural scaffolds found in bioactive natural products and pharmaceutical compounds from gold‐catalyzed reactions of 1, n‐ diyne carbonates and esters. It covers the advances made through exploiting the reactivity of the substrate class triggered by an initial 1,2‐ or 1,3‐acyloxy migration of the propargyl motif as well as one rare example of a concerted double cyclization pathway.