Rhodium(II)‐Catalysed Skeletal Rearrangement of Ether Tethered  N ‐Sulfonyl 1,2,3‐Triazoles: a Rapid Approach to 2‐Aminoindanone and Dihydroisoquinoline Derivatives | Zendy

Yu Yinghua | Zendy; Zhu Lei | Zendy; Liao Yun | Zendy; Mao Zhifeng | Zendy; Huang Xueliang | Zendy

Premium

Rhodium(II)‐Catalysed Skeletal Rearrangement of Ether Tethered N ‐Sulfonyl 1,2,3‐Triazoles: a Rapid Approach to 2‐Aminoindanone and Dihydroisoquinoline Derivatives

Author(s) -

Yu Yinghua,

Zhu Lei,

Liao Yun,

Mao Zhifeng,

Huang Xueliang

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201501178

Subject(s) - chemistry , rhodium , vicinal , sulfonyl , carbene , ether , catalysis , stereochemistry , combinatorial chemistry , organic chemistry , alkyl

The skeletal rearrangement of ether tethered N ‐sulfonyl‐1,2,3‐triazoles has been achieved by rhodium(II) catalysis. This method offers a rapid entry to 2‐aminoindanone and dihydroisoquinoline architectures which can be further transformed to other valuable building blocks, such as vicinal aminoindanols, isoquinolines and isoquinolinones. A pathway involving an azavinyl rhodium carbene intermediate was proposed according to a preliminary mechanistic study.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research