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One for Many: A Universal Reagent for Acylation Processes
Author(s) -
Moon Hyun Kyung,
Sung Gi Hyeon,
Kim Bo Ram,
Park Jong Keun,
Yoon YongJin,
Yoon Hyo Jae
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201501177
Subject(s) - acylation , chemistry , reagent , substrate (aquarium) , combinatorial chemistry , catalysis , yield (engineering) , organic chemistry , oceanography , materials science , metallurgy , geology
This work describes acylation reactions facilitated by a type of heterocycle‐based acyl transfer agent, 2‐acyloxypyridazinone. Reactions of 2‐acyloxypyridazinone with carboxylic acids yield mixed carbonic anhydride intermediates, which are reactive and could be coupled with a wide range of substrates including acids, amines, alcohols, and thiols. The wide substrate scope, ease of operation (no additive or catalyst), storage and handling stability, and atom‐efficiency from recycling the heterocycle carrier make the reported acylating agent attractive for acylation‐based coupling reactions.