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Copper‐Catalyzed Diastereoselective Synthesis of Trifluoromethylated Tetrahydrofurans
Author(s) -
Wang Yanan,
Jiang Min,
Liu JinTao
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201501166
Subject(s) - chemistry , reagent , intramolecular force , catalysis , copper , combinatorial chemistry , organic chemistry
The copper‐catalyzed intramolecular diastereoselective trifluoromethylcycloetherification of homoallylic alcohols with Togni’s reagent as trifluoromethylating reagent was realized under mild conditions. Various trifluoromethylated tetrahydrofurans were synthesized in moderate to good yields. Moreover, a wide range of common functional groups was tolerated.