Four‐Electron Electrocyclic Ring‐Opening/Intermolecular [4+2] Cycloadditions of α‐Hydroxycyclobutenones: Stereoselective Synthesis of Multiple Substituted δ‐Lactams | Zendy

Song Peidong | Zendy; Li Qing | Zendy; Wang Congcong | Zendy; Wu Wenfa | Zendy; Mao Xu | Zendy; Wang Jiajia | Zendy; Hu Xiangdong | Zendy

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Four‐Electron Electrocyclic Ring‐Opening/Intermolecular [4+2] Cycloadditions of α‐Hydroxycyclobutenones: Stereoselective Synthesis of Multiple Substituted δ‐Lactams

Author(s) -

Song Peidong,

Li Qing,

Wang Congcong,

Wu Wenfa,

Mao Xu,

Wang Jiajia,

Hu Xiangdong

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201501152

Subject(s) - chemistry , stereoselectivity , intermolecular force , cycloaddition , ketene , ring (chemistry) , electrocyclic reaction , enol , intramolecular force , stereochemistry , computational chemistry , photochemistry , medicinal chemistry , organic chemistry , molecule , catalysis

A four‐electron electrocyclic ring‐opening/intermolecular [4+2] cycloaddition of α‐hydroxycyclobutenones is reported. The reaction represents the first example for the intermolecular cycloaddition of the extensively studied enol‐ketene intermediate, and provides a new synthetic route to multiply substituted δ ‐lactams in high stereoselectivity.

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