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Palladium‐Catalyzed Tandem Reaction of Alkyne‐Based Aryl Iodides and Salicyl N ‐Tosylhydrazones to Construct the Spiro[benzofuran‐3,2′‐chromene] Skeleton
Author(s) -
Shang Xue Song,
Li Nian Tai,
Li Deng Yuan,
Liu Pei Nian
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201501150
Subject(s) - chemistry , benzofuran , alkyne , palladium , aryl , intramolecular force , catalysis , combinatorial chemistry , cascade reaction , tandem , medicinal chemistry , organic chemistry , alkyl , materials science , composite material
A convenient palladium‐catalyzed tandem reaction of aryl iodides and salicyl N ‐tosylhydrazones has been achieved to afford a series of compounds containing the novel spiro[benzofuran‐3,2′‐chromene] scaffold in moderate to good yields. This efficient catalytic reaction, which tolerates various functional groups, combines alkyne‐based 5‐ exo ‐ dig cyclization, palladium(II) carbene migratory insertion and intramolecular cyclization, generating three new bonds in one reaction.