Premium
Back Cover: Iridium‐Catalyzed [2+2+2] Cycloaddition of α,ω‐Diynes with Cyanamides (Adv. Synth. Catal. 18/2015)
Author(s) -
Hashimoto Toru,
Ishii Satoshi,
Yano Reiko,
Miura Hiroki,
Sakata Ken,
Takeuchi Ryo
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201501081
Subject(s) - cycloaddition , iridium , nitrile , chemistry , regioselectivity , catalysis , alkyne , reactivity (psychology) , medicinal chemistry , organic chemistry , medicine , alternative medicine , pathology
The back cover picture , provided by Ryo Takeuchi and co‐workers, illustrates the iridium‐catalyzed [2+2+2] cycloaddition of α,ω‐diynes with cyanamides. The iridium catalyst is efficient for the atom‐economical synthesis of multi‐substituted aminopyridines. Regioselective cycloaddition is achieved in case of α,ω‐diynes possessing two different internal alkyne moieties. Cyanamides are more reactive than nitriles. This higher reactivity of cyanamide than nitrile was analyzed based on density functional theory calculations at the B3LYP level. Details can be found in the full paper on pages 3901–3916 (T. Hashimoto, S. Ishii, R. Yano, H. Miura, K. Sakata, R. Takeuchi, Adv. Synth. Catal. 2015 , 357 , 3901–3916; DOI: 10.1002/adsc.201500637 ).