Transition Metal‐Free Synthesis of 3‐Alkynylpyrrole‐2‐carboxylates  via  Michael Addition/Intramolecular Cyclodehydration | Zendy

Teng Qinghu | Zendy; Xu Yanli | Zendy; Liang Ying | Zendy; Wang Hengshan | Zendy; Wang Yingchun | Zendy; Pan Yingming | Zendy

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Transition Metal‐Free Synthesis of 3‐Alkynylpyrrole‐2‐carboxylates via Michael Addition/Intramolecular Cyclodehydration

Author(s) -

Teng Qinghu,

Xu Yanli,

Liang Ying,

Wang Hengshan,

Wang Yingchun,

Pan Yingming

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201501073

Subject(s) - chemistry , intramolecular force , michael reaction , glycine , transition metal , transformation (genetics) , combinatorial chemistry , organic chemistry , stereochemistry , catalysis , amino acid , biochemistry , gene

A transition metal‐free and efficient method for the synthesis of 3‐alkynylpyrrole‐2‐carboxylates from diynones and glycine esters or 2‐aminoacetophenone hydrochloride has been developed. This transformation provides a large range of substituted pyrroles in good to excellent yields with the elimination of water as the only by‐product. The detailed mechanistic studies elucidated that this transformation involves a Michael addition/intramolecular cyclodehydration process.

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