Palladium‐Catalyzed C‐7 Selective CH Carbonylation of Indolines for Expedient Synthesis of Pyrroloquinazolinediones | Zendy

Wang PeiLong | Zendy; Li Yan | Zendy; Ma Lan | Zendy; Luo ChenGuang | Zendy; Wang ZhenYu | Zendy; Lan Quan | Zendy; Wang XiSheng | Zendy

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Palladium‐Catalyzed C‐7 Selective CH Carbonylation of Indolines for Expedient Synthesis of Pyrroloquinazolinediones

Author(s) -

Wang PeiLong,

Li Yan,

Ma Lan,

Luo ChenGuang,

Wang ZhenYu,

Lan Quan,

Wang XiSheng

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201501070

Subject(s) - chemistry , carbonylation , palladium , carbon monoxide , catalysis , yield (engineering) , benzoquinone , derivative (finance) , combinatorial chemistry , indole test , organic chemistry , photochemistry , materials science , economics , financial economics , metallurgy

A novel palladium‐catalyzed C‐7 selective CH carbonylation of indolines with carbon monoxide for an expedient synthesis of pyrroloquinazolinediones, a structural motif with great potential in biologically active compounds, has been developed. Oxidation of the pyrroloquinazolinedione with 2,3‐dichloro‐5,6‐dicyano‐ p ‐benzoquinone (DDQ) could easily afford the corresponding indole‐based derivative in excellent yield.

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