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Palladium‐Catalyzed C‐7 Selective CH Carbonylation of Indolines for Expedient Synthesis of Pyrroloquinazolinediones
Author(s) -
Wang PeiLong,
Li Yan,
Ma Lan,
Luo ChenGuang,
Wang ZhenYu,
Lan Quan,
Wang XiSheng
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201501070
Subject(s) - chemistry , carbonylation , palladium , carbon monoxide , catalysis , yield (engineering) , benzoquinone , derivative (finance) , combinatorial chemistry , indole test , organic chemistry , photochemistry , materials science , economics , financial economics , metallurgy
A novel palladium‐catalyzed C‐7 selective CH carbonylation of indolines with carbon monoxide for an expedient synthesis of pyrroloquinazolinediones, a structural motif with great potential in biologically active compounds, has been developed. Oxidation of the pyrroloquinazolinedione with 2,3‐dichloro‐5,6‐dicyano‐ p ‐benzoquinone (DDQ) could easily afford the corresponding indole‐based derivative in excellent yield.