Premium
Iridium(III)‐Catalyzed Direct CH Sulfonamidation of 2‐Aryl‐1,2,3‐triazole N ‐Oxides with Sulfonyl Azides
Author(s) -
Zhu Bingfeng,
Cui Xiuling,
Pi Chao,
Chen Dong,
Wu Yangjie
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201501036
Subject(s) - chemistry , sulfonyl , regioselectivity , aryl , catalysis , iridium , combinatorial chemistry , triazole , 1,2,3 triazole , functional group , medicinal chemistry , organic chemistry , alkyl , polymer
We have developed a method for the direct sulfonamidation of 2‐aryl‐1,2,3‐triazole N ‐oxides using sulfonyl azides as the amino source to release molecular nitrogen as the sole by‐product. This protocol exhibits excellent functional group tolerance and proceeds efficiently under external oxidant‐free conditions. Various 2‐(2‐sulfonamidoaryl)‐1,2,3‐triazoles were prepared in up to 97% yields for 25 examples with excellent regioselectivity.