Cover Picture: Synthesis of 4‐Aryl‐2‐Quinolones via Copper‐Catalyzed Hydroarylation of ( o ‐Aminophenyl)propiolates with Arylboronates (Adv. Synth. Catal. 2/2016)

The front cover image , provided by Yoshihiko Yamamoto, illustrates an efficient modular synthesis of 4‐aryl‐2(1 H )‐quinolones via one‐pot hydroarylation/cyclization. The hydroarylation of orthogonally protected ( o ‐aminophenyl)propiolates with arylboronic acid neopentyl glycol esters under mild conditions using Cu(OAc) 2 as a catalyst in methanol and the subsequent acidic removal of a Boc group afforded the 4‐aryl‐2‐quinolones. The ( o ‐aminophenyl)propiolate substrates were prepared by desilylative carboxylation of the corresponding silylalkynes using carbon dioxide as a ubiquitous C 1 source. Details can be found in the communication on pages 166–171 (T. Murayama, M. Shibuya, Y. Yamamoto, Adv. Synth. Catal. 2016 , 358 , 166–171; DOI: 10.1002/adsc.201500837 ).