Premium
Inside Cover: Fluorinated Alcohol‐Mediated S N 1‐Type Reaction of Indolyl Alcohols with Diverse Nucleophiles (Adv. Synth. Catal. 18/2015)
Author(s) -
Wen Hao,
Wang Liang,
Xu Lubin,
Hao Zhihui,
Shao ChangLun,
Wang ChangYun,
Xiao Jian
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201501001
Subject(s) - chemistry , nucleophile , alcohol , catalysis , scope (computer science) , substrate (aquarium) , medicinal chemistry , cover (algebra) , reaction conditions , combinatorial chemistry , organic chemistry , mechanical engineering , oceanography , computer science , engineering , programming language , geology
The inside cover picture , provided by Jian Xiao, Chang‐Lun Shao and co‐workers, illustrates an efficient S N 1‐type reaction of 3‐indolylmethanols with miscellaneous nucleophiles, featuring a catalyst‐free procedure, low cost, wide substrate scope and mild reaction conditions. This approach provides a green and efficient method for synthesis of diverse 3‐substituted indolyl derivatives as well as unsymmetrical bisindolylmethanes and triarylmethanes. Moreover, this methodology overcomes the difficulties in acid‐catalyzed 3‐indolylmethanol‐involved reactions, which contributes greatly to the chemistry of 3‐indolylmethanols. Details can be found in the Update on pages 4023–4030 (H. Wen, L. Wang, L. Xu, Z. Hao, C.‐L. Shao, C.‐Y. Wang, J. Xiao, Adv. Synth. Catal. 2015 , 357 , 4023–4030; DOI: 10.1002/adsc.201500500 ).