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Copper(I)‐Catalysed Multicomponent Reaction: Straightforward Access to 5‐Hydroxy‐1 H ‐pyrrol‐2(5 H )‐ones
Author(s) -
Mardjan Muhammad Idham Darussalam,
Parrain JeanLuc,
Commeiras Laurent
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500994
Subject(s) - chemistry , copper , combinatorial chemistry , natural product , reaction conditions , product (mathematics) , terminal (telecommunication) , coupling reaction , catalysis , organic chemistry , stereochemistry , telecommunications , geometry , mathematics , computer science
A copper‐catalysed multicomponent coupling reaction between readily available ( Z )‐3‐iodoacrylic acids, terminal alkynes, and primary amines was developed to smoothly access a small library of 5‐hydroxy‐1 H ‐pyrrol‐2(5 H )‐ones in good yields. This practical and general process was applied to a short‐steps synthesis of the natural product pulchellalactam.