Copper‐Nitrene Triggered Annulation of α‐Acyl Cinnamides: Access to Isoxazol‐3(2 H )‐ones | Zendy

Yu Mangfei | Zendy; Zhang Qian | Zendy; Li Gong | Zendy; Yuan Jingwen | Zendy; Zhang Ning | Zendy; Zhang Rui | Zendy; Liang Yongjiu | Zendy; Dong Dewen | Zendy

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Copper‐Nitrene Triggered Annulation of α‐Acyl Cinnamides: Access to Isoxazol‐3(2 H )‐ones

Author(s) -

Yu Mangfei,

Zhang Qian,

Li Gong,

Yuan Jingwen,

Zhang Ning,

Zhang Rui,

Liang Yongjiu,

Dong Dewen

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201500990

Subject(s) - chemistry , annulation , intramolecular force , nitrene , copper , tandem , sequence (biology) , combinatorial chemistry , michael reaction , catalysis , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , materials science , composite material

A facile and efficient one‐pot synthesis of isoxazol‐3(2 H )‐ones has been developed starting from α‐acyl cinnamides and tosyliminophenyliodinane catalyzed by copper(II) acetate [Cu(OAc) 2 ] under very mild conditions involving a tandem aza‐Michael addition and intramolecular cyclization sequence.

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