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Copper‐Nitrene Triggered Annulation of α‐Acyl Cinnamides: Access to Isoxazol‐3(2 H )‐ones
Author(s) -
Yu Mangfei,
Zhang Qian,
Li Gong,
Yuan Jingwen,
Zhang Ning,
Zhang Rui,
Liang Yongjiu,
Dong Dewen
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500990
Subject(s) - chemistry , annulation , intramolecular force , nitrene , copper , tandem , sequence (biology) , combinatorial chemistry , michael reaction , catalysis , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , materials science , composite material
A facile and efficient one‐pot synthesis of isoxazol‐3(2 H )‐ones has been developed starting from α‐acyl cinnamides and tosyliminophenyliodinane catalyzed by copper(II) acetate [Cu(OAc) 2 ] under very mild conditions involving a tandem aza‐Michael addition and intramolecular cyclization sequence.