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Direct Synthesis of Primary Amines via Ruthenium‐Catalysed Amination of Ketones with Ammonia and Hydrogen
Author(s) -
GallardoDonaire Joan,
Ernst Martin,
Trapp Oliver,
Schaub Thomas
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500968
Subject(s) - chemistry , ruthenium , amination , catalysis , trifluoromethanesulfonate , primary (astronomy) , reductive amination , ammonia , combinatorial chemistry , organic chemistry , hydrogen , atom economy , physics , astronomy
Abstract A highly selective reductive amination of ketones to primary amines with ammonia and hydrogen using a simple ruthenium catalyst has been developed. The protocol described constitutes an efficient and direct atom‐economical approach en route to α‐methylbenzylamine derivatives in good to high yields. The presence of catalytic amounts of aluminum triflate turned out to be crucial for achieving high conversion towards primary amines.