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Rhodium(III)‐Catalyzed Synthesis of Indole Derivatives From Pyrimidyl‐Substituted Anilines and Diazo Compounds
Author(s) -
Yu Ke,
Liang Yujie,
Li Bin,
Wang Baiquan
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500954
Subject(s) - chemistry , indole test , diazo , regioselectivity , annulation , rhodium , catalysis , functional group , tandem , combinatorial chemistry , intermolecular force , organic chemistry , molecule , materials science , composite material , polymer
An efficient method for the synthesis of indole derivatives from readily available pyrimidyl‐substituted anilines and diazo compounds via rhodium(III)‐catalyzed CH bond activation has been developed. This cyclization reaction displays excellent functional group compatibility and regioselectivity, which overcomes some drawbacks of the classical indole synthetic methods and provides a facile approach for the construction of multi‐substituted indole derivatives. The redox‐neutral intermolecular annulation procedure comprises tandem CH bond activation, cyclization, and condensation steps, releasing water and nitrogen as by‐products.