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Synthesis of Exocyclic Trisubstituted Alkenes via Nickel‐ Catalyzed Kumada‐Type Cross‐Coupling Reaction of gem ‐ Difluoroalkenes with Di‐Grignard Reagents
Author(s) -
Dai Wenpeng,
Zhang Xuxue,
Zhang Juan,
Lin Yingyin,
Cao Song
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500889
Subject(s) - chemistry , reagent , catalysis , nickel , coupling reaction , grignard reagent , combinatorial chemistry , organic chemistry
A practical, nickel‐catalyzed Kumada‐type double cross‐coupling reaction of gem ‐difluoroalkenes with 1,4‐ or 1,5‐di‐Grignard reagents was developed. The reaction proceeded efficiently at room temperature and a variety of cyclization products, arylmethylenecyclopentanes and arylmethylenecyclohexanes, were obtained in high to excellent yields, respectively.