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What Happens When the Terminal Aromatization is Blocked? Construction of 1,2‐Dihydroquinoline Derivatives by sp 3 CH Bond Oxidation of N ‐Arylalaninates
Author(s) -
Lü Shiwei,
Zhu Yingzu,
Ma Xingge,
Jia Xiaodong
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500885
Subject(s) - aromatization , chemistry , catalysis , functional group , scope (computer science) , salt (chemistry) , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , computer science , programming language , polymer
Using an aromatization‐blocked strategy, the 1,2‐dihydroquinoline skeleton was efficiently constructed by sp 3 CH bond oxidation of N ‐arylalaninates under catalytic radical cation salt‐promoted conditions. Investigation of the reaction scope shows broad generality and good functional group tolerance. This method provides a new way to synthesize 1,2‐dihydroquinoline derivatives from easily accessible starting materials.