What Happens When the Terminal Aromatization is Blocked? Construction of 1,2‐Dihydroquinoline Derivatives by  sp  3  CH Bond Oxidation of  N ‐Arylalaninates | Zendy

Lü Shiwei | Zendy; Zhu Yingzu | Zendy; Ma Xingge | Zendy; Jia Xiaodong | Zendy

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What Happens When the Terminal Aromatization is Blocked? Construction of 1,2‐Dihydroquinoline Derivatives by sp 3 CH Bond Oxidation of N ‐Arylalaninates

Author(s) -

Lü Shiwei,

Zhu Yingzu,

Ma Xingge,

Jia Xiaodong

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201500885

Subject(s) - aromatization , chemistry , catalysis , functional group , scope (computer science) , salt (chemistry) , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , computer science , programming language , polymer

Using an aromatization‐blocked strategy, the 1,2‐dihydroquinoline skeleton was efficiently constructed by sp 3 CH bond oxidation of N ‐arylalaninates under catalytic radical cation salt‐promoted conditions. Investigation of the reaction scope shows broad generality and good functional group tolerance. This method provides a new way to synthesize 1,2‐dihydroquinoline derivatives from easily accessible starting materials.

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