Miyaura Borylation and One‐Pot Two‐Step Homocoupling of Aryl Chlorides and Bromides under Solvent‐Free Conditions | Zendy

Dzhevakov Pavel B. | Zendy; Topchiy Maxim A. | Zendy; Zharkova Daria A. | Zendy; Morozov Oleg S. | Zendy; Asachenko Andrey F. | Zendy; Nechaev Mikhail S. | Zendy

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Miyaura Borylation and One‐Pot Two‐Step Homocoupling of Aryl Chlorides and Bromides under Solvent‐Free Conditions

Author(s) -

Dzhevakov Pavel B.,

Topchiy Maxim A.,

Zharkova Daria A.,

Morozov Oleg S.,

Asachenko Andrey F.,

Nechaev Mikhail S.

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201500844

Subject(s) - borylation , chemistry , palladium , aryl , halide , ligand (biochemistry) , solvent , combinatorial chemistry , catalysis , organic chemistry , biochemistry , alkyl , receptor

Solvent‐free protocols for Miyaura borylation and the one‐pot, two‐step homocoupling of aryl halides are reported for the first time. Bis(dibenzylideneacetone)palladium(0) [Pd(dba) 2 ] is an optimal source of palladium for Miyaura borylation, while for one‐pot two‐step homocoupling palladium(II) acetate [Pd(OAc) 2 ] gives highest yields. Aryl bromides are coupled most efficiently using the DPEphos ligand. Chlorides are coupled using XPhos. The developed protocols are robust, versatile and easily reproducible on a large scale.

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