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Design and Synthesis of 2‐Methyl‐7‐aminobenzoxazole as Auxiliary in the Palladium(II)‐Catalyzed Arylation of a beta ‐Positioned C( sp 3 )H Bond
Author(s) -
Luo Feihua,
Yang Jun,
Li Zhengkai,
Xiang Haifeng,
Zhou Xiangge
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500834
Subject(s) - chemistry , palladium , catalysis , selectivity , beta (programming language) , substrate (aquarium) , stereochemistry , compatibility (geochemistry) , methylene , medicinal chemistry , organic chemistry , oceanography , computer science , programming language , geology , geochemistry
A palladium(II)‐catalyzed direct arylation of methylene C( sp 3 )H bonds by 2‐methyl‐7‐aminobenzoxazole as an effective auxiliary is reported. This process exhibited high beta ‐site selectivity, broad substrate scope, and compatibility with different functional groups with moderate to high yields up to 89%.