Enantiopure  N ‐Benzyloxycarbonyl‐β 2 ‐amino Acid Allyl Esters from Racemic β‐Lactams by Dynamic Kinetic Resolution using  Candida antarctica  Lipase B | Zendy

Gianolio Eleonora | Zendy; Mohan Resmi | Zendy; Berkessel Albrecht | Zendy

Premium

Enantiopure N ‐Benzyloxycarbonyl‐β 2 ‐amino Acid Allyl Esters from Racemic β‐Lactams by Dynamic Kinetic Resolution using Candida antarctica Lipase B

Author(s) -

Gianolio Eleonora,

Mohan Resmi,

Berkessel Albrecht

Publication year - 2016

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201500820

Subject(s) - candida antarctica , enantiopure drug , kinetic resolution , chemistry , lipase , resolution (logic) , hydrolysis , organic chemistry , catalysis , stereochemistry , enzyme , enantioselective synthesis , artificial intelligence , computer science

The dynamic kinetic resolution of α‐substituted racemic β‐lactams by alcoholytic ring‐opening, catalyzed by immobilized lipase B from Candida antarctica is described. With this process, a variety of racemic α‐substituted N ‐Cbz‐azetidinones (Cbz=benzyloxycarbonyl) was transformed to the corresponding N ‐Cbz‐protected β 2 ‐amino acid allyl esters with high enantioselectivity (up to 99%) and high yields (up to quantitative) at room temperature.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research