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Regioselective Copper‐Catalyzed Oxidative Cross‐Coupling of Imidazo[1,2‐ a ]pyridines with Methyl Ketones: An Efficient Route for Synthesis of 1,2‐Diketones
Author(s) -
Lei Sai,
Chen GuiJun,
Mai Yingying,
Chen Longbin,
Cai Huiyin,
Tan Jingwen,
Cao Hua
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500803
Subject(s) - chemistry , regioselectivity , catalysis , oxidative coupling of methane , pyridine , oxidative phosphorylation , copper , oxygen , molecular oxygen , environmentally friendly , medicinal chemistry , organic chemistry , combinatorial chemistry , biochemistry , ecology , biology
An efficient copper‐catalyzed oxidative coupling of imidazo[1,2‐ a ]pyridines with methyl ketones to directly generate structurally sophisticated 1,2‐dicarbonyl imidazo[1,2‐ a ]pyridine derivatives under oxidative conditions is described. The reaction proceeds in good yields using the environmental friendly molecular oxygen as the oxidant. 18 O‐Labelling experiments unambiguously established that the oxygen of the dicarbonyl products originated from oxygen rather than from water.