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Direct Introduction of Dithiocarbamates onto Imidazoheterocycles under Mild Conditions
Author(s) -
Jiao Jing,
Wei Liang,
Ji XiaoMing,
Hu MaoLin,
Tang RiYuan
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500780
Subject(s) - chemistry , imidazole , iodine , combinatorial chemistry , dithiocarbamate , organic chemistry
This paper discloses an iodine‐mediated CH thiolation strategy for introduction of dithiocarbamates onto imidazoheterocycles under mild conditions. Imidazole derivatives, including imidazopyridines, imidazothiazoles, and benzoimidazoles, were well tolerated to afford diverse imidazoheterocycles‐dithiocarbamates compounds. These compounds are expected to be significant for drug discovery.