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Palladium‐Catalyzed Aminocarbonylation Reaction to Access 1,3,4‐Oxadiazoles using Chloroform as the Carbon Monoxide Source
Author(s) -
Li Zhengyi,
Wang Liang
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500778
Subject(s) - chemistry , chloroform , carbon monoxide , aryl , palladium , catalysis , halide , carbonylation , hydroxide , organic chemistry , combinatorial chemistry , inorganic chemistry , alkyl
Abstract A palladium‐catalyzed aminocarbonylation reaction of aryl halides with chloroform and tetrazoles has been developed, where chloroform was employed as the carbon monoxide (CO) source in the presence of cesium hydroxide. The in situ generated N ‐acylated tetrazoles were unstable and easily decomposed to afford 2,5‐disubstituted 1,3,4‐oxadiazoles. A wide range of tetrazoles and aryl halides reacted smoothly under the optimized reaction conditions to give the corresponding products in moderate to good yields.