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Rhodium(III)‐Catalyzed Synthesis of Aryl Spirocycles by Aromatic CH Activation/Intramolecular Heck‐Type Reaction
Author(s) -
Chabaud Laurent,
Raynal Quentin,
Barre Elvina,
Guillou Catherine
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500768
Subject(s) - intramolecular force , chemistry , rhodium , aryl , catalysis , ring (chemistry) , steric effects , combinatorial chemistry , heck reaction , natural product , organic chemistry , medicinal chemistry , palladium , alkyl
The rhodium(III)‐catalyzed aromatic CH activation/intramolecular Heck‐type reaction has been studied to synthesize spirocyclic compounds, an important class of molecules in medicinal chemistry and natural product synthesis. This approach was efficient with a variety of substituted N ‐methoxybenzamides tethered to different cyclic alkenes having a 5‐, 6‐ or 7‐membered ring. This practical method affords sterically hindered o ‐substituted aryl spirocycles that are valuable compounds for further functionalization to access relevant building blocks.