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Palladium and Copper Cocatalyzed Intermolecular Cyclization Reaction: Synthesis of 5‐Aminopyrazole Derivatives
Author(s) -
Ma Chaowei,
Wen Ping,
Li Jihui,
Han Xu,
Wu Zhaoyang,
Huang Guosheng
Publication year - 2016
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500767
Subject(s) - acetonitriles , chemistry , palladium , intermolecular force , copper , reactivity (psychology) , combinatorial chemistry , catalysis , organic chemistry , molecule , acetonitrile , medicine , alternative medicine , pathology
A novel and efficient palladium and copper co‐catalyzed intermolecular cyclization of acetonitriles with hydrazones has been developed for the synthesis of 5‐aminopyrazoles through CC and CN bond formation. The reaction has the advantages of easily available starting materials, simple manipulation and mild reaction conditions. The reaction involving various substituted acetonitriles and hydrazones proceeds smoothly and 5‐aminopyrazoles are synthesized in good yields. In contrast to the aliphatic and heteroaromatic substrates, the aromatic substrates tend to have a higher degree of reactivity.