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Inside Cover: Enantioselective α‐Alkylation of Benzylideneamino tert ‐Butyl Malonates by Phase‐Transfer Catalysis (Adv. Synth. Catal. 13/2015)
Author(s) -
Park Cheonhyoung,
Ha Min Woo,
Kim Byungsoo,
Hong Suckchang,
Kim Doyoung,
Park Yohan,
Kim Mihyun,
Lee Jae Kyun,
Lee Jeeyeon,
Park Hyeunggeun
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500751
Subject(s) - chemistry , enantioselective synthesis , alkylation , catalysis , medicinal chemistry , bromide , ammonium , organic chemistry
The inside cover picture , provided by Hyeung‐geun Park and co‐workers, illustrates an enantioselective phase‐transfer catalytic α‐alkylation of benzylideneamino tert ‐butyl malonates. This highly efficient protocol was promoted by a quaternary ammonium catalyst, ( S , S )‐NAS bromide, and the corresponding α,α‐dialkylmalonates, bearing a quaternary chiral carbon center, were obtained in high yields and with high stereoselectivities. The products were then selectively hydrolyzed to chiral malonic monoacids under basic, acidic, or catalytic hydrogenation conditions. Details can be found in the full paper on pages 2841–2848 (C. Park, M. W. Ha, B. Kim, S. Hong, D. Kim, Y. Park, M.‐h. Kim, J. K. Lee, J. Lee, H.‐g. Park, Adv. Synth. Catal. 2015 , 357 , 2841–2848; DOI: 10.1002/adsc.201500560).