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A Combination of Metal and Organic Catalysis: Highly Diastereo‐ and Enantioselective Construction of Fluorinated 2‐Aminocyclopenta[ b ]pyran Derivatives
Author(s) -
Peng Jiahuan,
Zhao BoLiang,
Du DaMing
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500744
Subject(s) - enantioselective synthesis , chemistry , pyran , organocatalysis , catalysis , lewis acids and bases , fluorine , combinatorial chemistry , organic chemistry , optically active , stereochemistry
An efficient highly diastereo‐ and enantioselective protocol to access optically pure fluorine‐containing 2‐amino‐cyclopenta[ b ]pyran derivatives using Lewis acid catalysis and organocatalysis sequence has been developed. The corresponding products could be obtained in good to excellent yields with good to excellent diastereoselectivity and enantioselectivity (up to 99:1 dr , >99% ee ).