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Cover Picture: Direct Construction of the 9 H ‐Pyrrolo[1,2‐ a ]azepin‐9‐amine Skeleton via [4+3] Annulation of Alkyl 2‐Aroyl‐1‐chlorocyclo‐ propanecarboxylates (Adv. Synth. Catal. 13/2015)
Author(s) -
Hu Junhao,
Liu Yang,
Gong Yuefa
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500739
Subject(s) - annulation , chemistry , alkyl , amine gas treating , pyrrole , reagent , pyrazine , medicinal chemistry , stereochemistry , combinatorial chemistry , catalysis , organic chemistry
The front cover picture , provided by Yuefa Gong and co‐workers, illustrates a highly diastereoselective approach for direct synthesis of the important 9 H ‐pyrrolo[1,2‐ a ]azepin‐9‐amines. This transition metal‐free [4+3] annulation reaction between donor‐acceptor reagents derived from 1 H ‐pyrrole‐2‐carbaldehydes and alkyl 2‐aroyl‐1‐chlorocyclopropanecarboxylates proceeded quickly under mild basic conditions, affording azepin‐9‐amine derivatives in moderate to high yields with high diastereoselectivities. Details can be found in the communication on pages 2781–2787 (J. Hu, Y. Liu, Y. Gong, Adv. Synth. Catal. 2015 , 357, 2781–2787; DOI: 10.1002/adsc.201500376 ).