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Iridium‐Catalyzed Enantioselective Hydrogenation of β,β‐Disubstituted Nitroalkenes
Author(s) -
Liu Man,
Kong Duanyang,
Li Meina,
Zi Guofu,
Hou Guohua
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500723
Subject(s) - iridium , enantioselective synthesis , chemistry , catalysis , asymmetric hydrogenation , organic chemistry , combinatorial chemistry
Abstract A highly efficient, iridium‐catalyzed, enantioselective hydrogenation of β,β‐disubstituted nitroalkenes has been developed. Using a complex consisting of iridium and ( S , S )‐f‐spiroPhos as the catalyst, a variety of β,β‐disubstituted nitroalkenes were successfully hydrogenated to the corresponding chiral nitroalkanes with excellent enantioselectivities (up to 98% ee ) and high turnover numbers (TON=1000).