Premium
Iron(III)/Iodine‐Catalyzed C( sp 2 )H Activation of α,β‐Unsaturated Aldehydes/Ketones with Amidines: Synthesis of 1,2,4,5‐Tetrasubstituted Imidazoles
Author(s) -
Wu Ping,
Qu Jinpeng,
Li Yaxuan,
Guo Xin,
Tang Dong,
Meng Xu,
Yan Rulong,
Chen Baohua
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500701
Subject(s) - chemistry , catalysis , iodine , functional group , ketone , amination , organic chemistry , combinatorial chemistry , medicinal chemistry , polymer
An efficient methodology to access a library of 1,2,4,5‐tetrasubstituted imidazoles from a broad range of amidines and α,β‐unsaturated aldehydes/ketones via a C( sp 2 )H amination has been developed. This method represents a new and simple way to prepare highly substituted imidazoles from easily available starting materials, inexpensive catalysts, and with good functional group tolerance in good to excellent yields.