Palladium‐Catalyzed Domino Process: Synthesis of Symmetrical Diarylalkynes,  cis ‐ and  trans ‐Alkenes using Lithium Acetylide as a Synthon | Zendy

Krishna Jonnada | Zendy; Krishna Reddy Alavala Gopi | Zendy; Satyanarayana Gedu | Zendy

Premium

Palladium‐Catalyzed Domino Process: Synthesis of Symmetrical Diarylalkynes, cis ‐ and trans ‐Alkenes using Lithium Acetylide as a Synthon

Author(s) -

Krishna Jonnada,

Krishna Reddy Alavala Gopi,

Satyanarayana Gedu

Publication year - 2015

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201500686

Subject(s) - chemistry , acetylide , palladium , synthon , catalysis , stereoselectivity , domino , amination , aryl , one pot synthesis , lithium (medication) , acetylene , combinatorial chemistry , organic chemistry , medicinal chemistry , medicine , alkyl , endocrinology

An efficient domino protocol has been developed for the synthesis of symmetrical diarylalkynes. Notably, the method was successful in the presence of a palladium catalyst without the support of a copper co‐catalyst. Significantly, the method enabled the use of the commercially available and cheap lithium acetylide ethylenediamine complex as a source of acetylene for the construction of dual CC bonds, with a wide range of compatibility towards various substituents of the aryl bromides/iodides. Significantly, this protocol was successfully applied to the synthesis of cis ‐ and trans ‐alkenes in a highly stereoselective manner in a sequential one‐pot process.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research