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Organocatalyzed Formal [4+2] Cycloaddition of in situ Generated Azoalkenes with Arylacetic Acids: An Efficient Approach to the Synthesis of 4,5‐Dihydropyridazin‐3(2 H )‐ones
Author(s) -
Li Xuanyi,
Gai Kuo,
Yuan Zhenbo,
Wu Jie,
Lin Aijun,
Yao Hequan
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500645
Subject(s) - chemistry , cycloaddition , in situ , catalysis , combinatorial chemistry , organic chemistry
An unprecedented [4+2] cycloaddition of in situ generated azoalkenes with arylacetic acids has been developed under the catalysis of isothiourea. The reaction provided an efficient approach to the synthesis of 4,5‐dihydropyridazin‐3(2 H )‐one derivatives in moderate to good yields (up to 95%).
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