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Direct Synthesis of Hemiaminal Ethers via a Three‐Component Reaction of Aldehydes, Amines and Alcohols
Author(s) -
Beltrán Álvaro,
Álvarez Eleuterio,
DíazRequejo M. Mar,
Pérez Pedro J.
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500588
Subject(s) - hemiaminal , chemistry , organic chemistry , component (thermodynamics) , aldehyde , ether , catalysis , combinatorial chemistry , physics , thermodynamics
The reaction of aldehydes, amines and alcohols usually leads to a series of equilibria from which isolation of one product is difficult to achieve. We have found that this three‐component reaction can be controlled and directed in an exclusive manner toward the formation of the hemiaminal ether. A series of 33 hemiaminal ethers has been obtained in high yields, from different aldehydes, amines and alcohols, under very mild conditions just with molecular sieves as promoter.