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Rhodium(III)‐Catalyzed Redox‐Neutral CH Annulation of Arylnitrones and Alkynes for the Synthesis of Indole Derivatives
Author(s) -
Zhou Zhi,
Liu Guixia,
Chen Yan,
Lu Xiyan
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500580
Subject(s) - chemistry , indole test , annulation , rhodium , nitrone , oxidizing agent , steric effects , catalysis , yield (engineering) , functional group , redox , combinatorial chemistry , surface modification , medicinal chemistry , organic chemistry , cycloaddition , materials science , polymer , metallurgy
By using a nitrone as the oxidizing directing group, a mild, practical and efficient rhodium(III)‐catalyzed CH functionalization for the synthesis of indole derivatives has been developed. This reaction obviates the need for an external oxidant and shows good functional group tolerance. The employment of a sterically hindered Mes group on the carbon center of the nitrone is crucial to produce indoles in high yield.