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Copper‐Catalyzed Domino Synthesis of Benzo[4,5]imidazo[1,2‐ a ]pyrimidin‐4(10 H )‐ones using Cyanamide as a Building Block
Author(s) -
Lou Zhenbang,
Wu Xudong,
Yang Haijun,
Zhu Changjin,
Fu Hua
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500577
Subject(s) - chemistry , cyanamide , domino , catalysis , copper , iodide , combinatorial chemistry , block (permutation group theory) , medicinal chemistry , organic chemistry , geometry , mathematics
An efficient and practical copper‐catalyzed domino synthesis of benzo[4,5]imidazo[1,2‐ a ]pyrimidin‐4(10 H )‐ones has been developed. The protocol uses N ‐(2‐halophenyl)‐3‐alkylpropiolamides and cyanamide as the starting materials, inexpensive copper(I) iodide and pipecolinic acid as the catalyst and ligand, and the corresponding products were obtained in moderate to good yields.