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Homogeneous Gold‐Catalyzed Cyclization Reactions of Alkynes with N ‐ and S ‐Nucleophiles
Author(s) -
Debrouwer Wouter,
Heugebaert Thomas S. A.,
Roman Bart I.,
Stevens Christian V.
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500520
Subject(s) - nucleophile , chemistry , homogeneous , catalysis , intramolecular force , homogeneous catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry , physics , thermodynamics
This review covers the formation of N ‐ and S ‐containing heterocycles, initiated by gold‐catalyzed nucleophilic attack of N ‐ or S ‐nucleophiles onto alkynes. These types of nucleophiles have been somewhat overlooked as compared to their C ‐ or O ‐counterparts in other reviews. In this particular work, their intramolecular gold‐mediated attack onto alkynes is reviewed in depth. It is structured in such a fashion that the reader will get a clear view of which substrates react in which cyclization mode.