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Cover Picture: Organocatalytic Enantioselective Michael Reaction of Malononitrile with β,β‐Disubstituted Nitroalkenes (Adv. Synth. Catal. 11/2015)
Author(s) -
Chen Shengwei,
Lou Qinxin,
Ding Yuyang,
Zhang Shasha,
Hu Wenhui,
Zhao Junling
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500489
Subject(s) - enantioselective synthesis , malononitrile , chemistry , thiourea , cinchona , organocatalysis , michael reaction , medicinal chemistry , catalysis , organic chemistry
The front cover picture , provided by Junling Zhao and co‐workers, illustrates an enantioselective Michael reaction of malononitrile to a‐substituted‐β‐nitroacrylates. This high efficient protocol was promoted by a cinchona alkaloid derived thiourea catalyst and the corresponding products, bearing quaternary chiral centers, were obtained in high yields and with high stereoselectivities. A dihydropyrrole derivative was readily obtained through Fe/HCl reduction of the product. Details can be found in the communication on pages 2437–2441 . (S. W. Chen, Q. X. Lou, Y. Y. Ding, S. S. Zhang, W. H. Hu, J. L. Zhao, Adv. Synth. Catal. 2015 , 357 , 2437–2441; DOI: 10.1002/adsc.201500079).

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